Best Nootropics For Anxiety and Stress Relief

Plenty of nootropic supplements are designed to relieve anxiety and maintain cognitive function, but some are more effective than others.

Best Nootropics For Anxiety and Stress Relief

Anxiety is a common problem, and it can lower the quality of life, make it hard to stay productive, and take part in certain social situations.

Many prescription drugs used to treat stress and anxiety are harmful or cause uncomfortable side effects.

Because of these problems, many people turn to natural supplements to find the best nootropics for anxiety.

There are many nootropics to choose from, and each one offers unique benefits that can help you reduce anxiety, elevate mood, and promote relaxation.

Top 6 Nootropics For Anxiety On The Market

  1. Mind Lab Pro — Best Nootropic For Anxiety Overall
  2. Noocube — Best Nootropic For Social Anxiety and Focus
  3. Genius Joy — Best Nootropic to Reduce Anxiety and Stress
  4. Onnit New Mood — Best Nootropic Supplement For Anxiety and Relaxation
  5. Science Aniracetam — Best Racetam Nootropic For Anxiety
  6. Science Phenibut — Best Synthetic Nootropic Drug For Anxiety

Best Nootropic For Anxiety Overall

The most effective nootropics for anxiety calm the mind and body. They do it naturally by addressing various aspects of overall mental health and brain function that result in wide-ranging benefits.

Mind Lab Pro
Best nootropic for anxiety

#1 Mind Lab Pro

Mind Lab Pro not only balances neurotransmitters to eliminate anxiety and boost mood, but it also contains synergistic ingredients that provide optimal brain performance so that you can focus without distraction.

Check the best price

Mind Lab Pro is a full-spectrum nootropic product that can help you reduce anxiety and stress. It contains various ingredients, including bacopa monnieri and rhodiola rosea, that can help provide a relaxed feeling.

The stack can erase the symptoms associated with the stress response like shakiness, tension, racing thoughts, and constant worry.

As a result, Mind Lab Pro can help you focus and avoid following distracting thoughts caused by anxiety. By doing so, this supplement can help you retain your ability to think and your cognitive functions while also allowing you to avoid anxious feelings.

Many people with anxiety disorders find their symptoms make it hard to think clearly, and Mind Lab Pro promotes mental clarity that can assist with those frustrating issues. Some benefits to mood can also help you limit social anxiety symptoms.

The combination of 11 natural ingredients works well for mood and brain health because they address neurotransmitters that regulate energy levels, the stress hormone cortisol, and cognition, making it a universal nootropic.


  • Works for acute anxiety and long-term anxiety disorders
  • Lowers high cortisol levels related to stress
  • 11 synergistic ingredients offer well-rounded effects like mental energy, anti-stress, and more
  • All-natural, GMO-free, vegan friendly
  • Great for emotional management


  • More expensive than some of the alternative nootropic supplements

Best Nootropic For Social Anxiety and Focus

Nootropics for social anxiety can be highly beneficial for introverts or those who suffer from high anxiety levels in social situations. The best social nootropics do a lot for mood and cognition, particularly verbal skills and memory.

Best for social anxiety

#2 Noocube

Noocube is a brilliant choice for severe anxiety and panic attacks as social anxiety symptoms. It helps with brain function, inhibitions, general anxiety, and distracting worries and fears.

Check the best price

Noocube combines a variety of vitamins, amino acids, herbs, and nootropics to encourage a reduction in social anxiety and a boost in mood.

The stack works with the signaling of neurotransmitters acetylcholine, dopamine, norepinephrine, and serotonin, which are often imbalanced in those who suffer from a social anxiety disorder.

It also contains compounds that induce tranquility and relaxation, including l-theanine and bacopa monnieri. These substances can also help with insomnia, restlessness, agitation, and other adverse effects of social anxiety.

Furthermore, these relaxing benefits work with other effects from Alpha-GPC and other components for better cognitive function. For example, stress and anxiety heighten cortisol levels because of the fight-or-flight response, which contributes to inflammation.

Consequently, Noocube offers antioxidant and anti-inflammatory qualities that can help balance out these negative social anxiety issues more than any of their nootropic competitors.

Plus, it doesn’t contain anxiety-causing stimulants, making it one of the best nootropics for social anxiety.


  • Targets several avenues to alleviate stress
  • May prevent panic attacks without the use of stimulants
  • Suitable for physical health effects of reducing inflammation
  • Excellent for memory, focus, and brain energy


  • Only available on the official website

Best Nootropic to Reduce Anxiety and Stress

The best nootropics for anxiety, stress, and related signs will provide initial effects to address the immediate anxiety symptoms. Unfortunately, a lot of the options fall flat because they are not potent enough or do not act quickly, but the top supplement for this purpose works wonders for many people.

Genius Joy
To reduce anxiety and stress

#3 Genius Joy

If you want a potent supplement to lead you away from stress and eliminate anxious feelings, then Genius Joy is the perfect option. It combines properties to improve the state of mind, calm nerves, and affect alertness without stimulating bothersome thought patterns.

Genius Joy is a superb choice for those who want to fight anxiety with powerful and rapid effects. The l-theanine will help to enhance cognition while simultaneously affecting the brain chemical GABA to demolish restless thoughts, resist stress, and improve brain performance.

It also contains n-acetyl-l-tyrosine that can balance the excitatory neurotransmitter norepinephrine, which can boost stress levels.

By influencing the receptors and other aspects of neuroscience, l-tyrosine will instill confidence and reduce the frustration caused by stress and anxiety.

Finally, including various B vitamins helps bring emotional stability to outlook and helps to increase the resilience to stress, anxiety, and depression.

The label is rounded off with rhodiola rosea, 5-HTP, and other beneficial compounds to enhance cognition.


  • Rapid results for stress and positive outlook
  • Suitable for mood swings and emotion management
  • Can improve focus, reaction time, and other cognitive abilities


  • The energetic feeling can be uncomfortable for some people
  • Not as powerful as some of their other nootropic supplements

Best Nootropic Supplement For Anxiety and Relaxation

Effective nootropics for anxiety help you relax both mentally and physically. Some options contain components that offer sedative properties, slow the mind, and allow focus without stimulation and nervousness.

Onnit New Mood
Best for anxiety and relaxation

#4 Onnit New Mood

Onnit New Mood is one of the most popular nootropics if you want pure relaxing joy. It can foster an optimistic perspective while providing relaxing qualities to the mind, body, and spirit.

Check the best price

Many nootropics for anxiety work subtly on alpha brain waves, brain cells, and neurotransmitters. But Onnit New Mood provides results with a quick onset to offer anti-stress features and couple them with a feeling of tranquil positivity.

This is because it utilizes the building blocks of serotonin, l-tryptophan, and 5-HTP to trigger a sense of calming happiness and lower glutamate amounts.

In addition, it combined chamomile and valerian root extract, both of which are known for calming symptoms associated with anxiety disorders. This makes it an excellent nootropic option for relaxing after a long, stressful day at work and provides a feeling of calm to your everyday routine.

Onnit New Mood also contains B vitamins, lemon balm, and magnesium to offer health benefits like peaceful sleep, amino acid production, gut normalcy, and more. These effects can eliminate some problems that commonly contribute to stress.


  • Potent relaxation to relieve stress
  • Can elevate mood naturally
  • Appropriate for sleep and panic attacks


  • Weak nootropic effects for cognitive ability
  • “Tranquility Blend” does not give amounts for every ingredient in the formula
  • It makes some people feel sleepy when taken during the day

Best Racetam Nootropic For Anxiety

Racetams are some of the most common smart drugs and nootropics for various purposes, offering different benefits. For example, some do not ease social anxiety or related feelings. However, some compounds suit this purpose perfectly.

Science Aniracetam
Best racetam for anxiety

#5 Science Aniracetam

The best substance for a balance of anti-anxiety qualities and nootropic performance is the aniracetam from, as it is pure, potent, and reasonably priced for guaranteed results.

Check the best price

Aniracetam is a potent, synthetic racetam nootropic known for improving mental processing and learning, but it can also regulate neurotransmitters that influence mood and social anxiety.

It may help improve blood flow to allow the brain to fight against cognitive decline that is often associated with heightened levels of anxiety.

Aniracetam may increase motivation and help with problem-solving when taken during stressful situations. Because of this, it can help reduce many of the indirect negative effects that coincide with stress, like distracting thoughts, panic, jitters, and more.

An anxiety disorder can also drain energy and cause fatigue, which aniracetam can also ease.

In addition, it acts as a central nervous stimulant, which makes it one of the premier nootropics for social anxiety and generalized anxiety and can help you power through a tough day.


  • Fast-acting results
  • Indirectly addresses signs of panic attacks
  • Great for mental energy and boosting alertness


  • Synthetic composition and extreme side effects compared with natural alternatives
  • Stimulant properties can have the opposite effect on anxiety for some users
  • It can be too potent for some people and cause high blood pressure

Best Synthetic Nootropic Drug For Anxiety

While we always prefer natural nootropics, some synthetic options can be highly effective for reducing tension, intrusive thoughts, and other signs of anxiousness that you may want to consider.

Science Phenibut HCL
Synthetic nootropic for anxiety

#6 Science Phenibut

If you need a quick solution for stress and anxiety, phenibut may be an option to boost the response to negative feelings so rapidly that it effectively halts the fear of panic attacks.

Check the best price

Phenibut works by influencing GABA receptors, so it will make you feel calm even in the harshest and most high-stress environments.

While it is usually not recommended for daily use, it can be a great temporary or occasional choice for those with an anxiety disorder or who need to overcome intense feelings of fear in social situations.

If you have trouble sleeping due to high-stress levels, this may be an option to ease insomnia and relax.

It may also help you concentrate if you have difficulty paying attention because of intrusive thoughts, catastrophic thinking, and other mental issues related to nervousness and restlessness.

While it rarely improves cognitive function directly, it can help with memory, learning, concentration, and more during high stress. It may also help with worsened brain fog due to distracting anxious thought patterns.


  • Rapid results make it an option for ceasing panic attacks
  • It helps build resilience to stress and improves short-term memory in anxiety-provoking atmospheres


  • Synthetic and can cause various side effects
  • It can be addictive with prolonged use, leading to tolerance and withdrawal
  • Potent and not recommended for daily use

The Most Effective Nootropic Ingredients To Stack For Anxiety

Besides supplements designed for relieving tension, there are specific ingredients that you can add to your stack or daily routine that may help to ease anxiety and relax the mind and body.


One of the most popular anti-anxiety compounds is the amino acid l-theanine, found in green tea. L-theanine readily crosses the blood-brain barrier to lessen alpha brain waves and glutamate.

Because of these effects on glutamate, the substance l-theanine promotes relaxation and can reduce anxiety levels without contributing to drowsiness or inhibiting cognitive processes.

L-theanine is natural, and research shows it can be quite effective when taken daily and may even help with long-term social anxiety (1).

Not only that, but since l-theanine promotes relaxation because it can increase dopamine production and concentrations of the neurotransmitter GABA, it can help with attention span, alertness, and the management of mental tension.

Bacopa Monnieri

Bacopa monnieri is an herb used as a component of traditional medicine practices that supply several beneficial qualities (2).

It is excellent for lowering cortisol levels, which is a hormone that has been connected to stress. It also offers benefits that are more long-term than some of the other nootropics.

In addition, bacopa monnieri can deal with stress because it can relieve the suffering caused by continuous stress or depression since it appears to affect the neurotransmitter serotonin synthesis.

Plus, it offers anti-inflammatory properties and provides a lot of antioxidants.

Lion’s Mane Mushroom

The benefits of Lion’s Mane Mushroom are mild compared to some of the other nootropics, but research shows that these fungi can be fabulous for low levels of energy and poor outlook (3).

It is also great for blood flow and blood pressure and may help to supply more oxygen and nutrients to the brain.

The result is an optimal nootropic for anxiety and depression that may also be beneficial for social anxiety, panic attacks, and bipolar disorder. Not only that but Lion’s Mane is clinically proven to impact adenosine receptors for overall heart health and physical leisure.


Ashwagandha is one of the best nootropics for social and generalized anxiety disorder because, much like l-theanine, it acts on the neurotransmitter GABA and mimics the effects of GABA in the brain (4). It also promotes healthy neurons and regulates cortisol.

This makes ashwagandha root extract a great addition to a stack designed for better mental performance and health and may help with anxiety and depression and insomnia, fatigue, and illnesses caused or worsened by mental and physical tension.

An ashwagandha supplement can relieve anxiety immediately but also helps with mental health long term.

Ginkgo Biloba

Ginkgo biloba offers many benefits, but the most well-known effects are related to age-related memory and learning decline (5). However, it can also have a positive quality for anxiety and depression.

While ginkgo biloba may not offer the tension-reducing and anti-stress features of some other supplements, it has a mild and prolonged result for lowering anxious thoughts and feelings.

Plus, it improves circulation, which may combat some of the physical ailments associated with lengthy periods of stress.

Rhodiola Rosea

Rhodiola rosea is alternative medicine used in many nootropics for social anxiety. It offers anti-anxiety qualities in small doses, especially when combined with components like the amino acid l-theanine or bacopa monnieri.

In some cases, it may even prevent stress and anxiety, depending on various factors.

Rhodiola rosea is also a good option because it can be used to treat premature aging and is known for boosting the neurotransmitters dopamine and serotonin (6).

When the substance acts to increase dopamine, acetylcholine, and serotonin, it contributes to a reduction in fatigue and allows you to feel motivated and energetic without inducing anxiety and depression.


Citicoline and other choline supplements like Alpha GPC are primarily known for impacting acetylcholine levels. Still, it may also reduce alpha waves to help treat mental disorders like anxiety (7).

People with Alzheimer’s disease often experience a mental illness that correlates with scant amounts of acetylcholine, so citicoline may not only improve memory but may also support a better state of mind.

In addition, taking nootropics with citicoline may also help with a focus that may lack in times of high stress.

Gotu Kola

Gotu kola is best known for improving circulation and blood flow, thereby becoming an option to treat swelling and inflammation and prevent blood clots.

However, neuroscience shows that gotu kola also crosses the blood-brain barrier to improve brain processes that influence memory, learning, motivation, and aging (8).

Used in conjunction with other nootropics like ashwagandha, tyrosine, or l-theanine, it may treat nervousness and tension.

There is some evidence that it can alter adenosine concentrations in the brain, leading to some evidence of a reduction in symptoms of depression, anxiety, and brain fog.

Vitamins B6, B9, B12

B vitamins are essential for various bodily functions because they create new blood cells, convert food into energy, maintain healthy skin, and regulate brain cells.

For example, vitamin B1 can balance blood sugar, and doing so can avoid anxiety, and B3 manages serotonin to prevent depression by balancing mood and vitality (9).

Another B vitamin that is clinically proven to offer anti-anxiety qualities similar to the top nootropics is B5 because it supports healthy adrenal glands.

This can help maintain a balanced mood without substantial changes throughout the day.


By striking inhibitory processes in the brain and lowering the activity of brain waves, synthetic Noopept can protect against glutamate toxicity and increase the expression of BDNF and NFG.

This is beneficial for nootropics and related effects, but it can also be good for tension and strain within the body and brain.

Furthermore, a sustained period of stress can contribute to poor learning, cloudiness in the brain, and other symptoms that Noopept addresses (10). Combined with natural nootropics like l-theanine or ashwagandha, it can be an excellent choice for abnormal anxiety.

Why Should You Choose Natural Anti Anxiety Nootropics?

There are many reasons why choosing natural nootropics for anxiety and stress is better. The most satisfactory approach for understanding those reasons is to compare the natural options with the alternatives.

Prescription drugs for depression or anxiety can certainly be effective, but they have many side effects, abuse potential, addiction, and other factors to consider.

For example, benzodiazepines are a popular drug choice as an anxiolytic, but they also cause poor memory and drowsiness and can be highly addictive.

Anti-depressants may also take a long time to work and can cause unintended changes in mood or personality in the long term. Therefore, it is necessary to keep effectiveness in mind.

While a doctor-prescribed drug can work well, the natural alternatives sometimes work better. In addition, they can be more affordable and easier to change if you decide the specific compound isn’t suitable for you.

Finally, you can feel reassured knowing that you are not putting a synthetic drug or chemical into your body that can lead to withdrawal and other distressing consequences. Instead, you can rest easy knowing you chose the natural method to better well-being.

What To Look For To Relieve Anxiety with Supplements?

To adequately address anxiety in the brain and body with the correct nootropics, you must discover some of the underlying issues of the mental health condition.

This will allow you to choose a product or create a stack for your unique individual needs.

The Root Cause of Anxiety Disorders

There are various causes of anxiety disorders, and it’s difficult to pinpoint the exact catalyst. Choosing a supplement means you want one that offers you the best benefits without causing unwanted effects.

For some people, the environment and current welfare are the number one cause. If this is the case, you will want to find a supplement that allows you to live in the moment and gain a positive perspective.

However, medical conditions, drastic changes in living situations, and traumatic experiences can all play a role.

If you have a medical problem that contributes, then balance nootropics that address the anxiety with those that help you persevere through the health issues.

Finally, genetics can play a role in the development of anxiety. Unfortunately, this is harder to address because it may present an imbalance in chemicals or personality traits that makes you susceptible to emotional reactions.

Imbalances of Neurotransmitters

Many people find that they have an ineffective balance of neurotransmitter signaling. If this is the case, then you can choose nootropics that address the specific substance that is imbalanced. Different neurotransmission imbalances cause different results.

Poor concentrations of glutamate and GABA regulate our response to stressful conditions and ability to adapt to a situation.

If this is the issue, you will probably be restless and fidgety most of the time. Consequently, you may have insomnia, panic attacks, muscle pain, involuntary movements, bad memory, and depression.

Acetylcholine imbalance can also lead to anxiety, but the primary symptoms will be associated with brain mentality problems and judgment lapses. You may become forgetful and have a hard time focusing on a task for more than a few minutes at a time.

Norepinephrine issues can cause tremors, hyperactivity, swings in energy and mood, lethargy, and a lack of motivation.

On the other hand, dopamine or serotonin imbalance is more likely to cause depression, apathy, and constant anxiety, making it hard to remain hopeful.

Physical symptoms may include nausea, appetite changes, weight loss or gain, muscle stiffness, and constipation.


Choosing the best supplements for stress and anxiety can be a hassle with so many options on the market.

Besides premixed formulas and blends designed for primary aspects of anxiety, there are also individual ingredients that you can stack on your own.

Popular options like l-theanine and l-tyrosine can have an immediate impact. In contrast, herbs including ashwagandha and bacopa monnieri are more likely to have a prolonged yet subtle and anxiolytic effect.

Therefore, it may take some time to discover the most suitable ingredients for you or the combination of nootropics that eliminates your negative feelings and accentuates your positive mental features.

Overall, we recommend Mind Lab Pro as it is the best anxiety supplement if you are looking for the perfect synergy of anxiolytic results and cognition-boosting powers.

The combination of l-tyrosine, vitamin B complex, citicoline, bacopa monnieri is proven to calm the brain, relax the mind, and improve mental capacities.