Best Lion’s Mane Mushroom Supplement (Capsules & Powder) — Top Brands of 2023

Get rid of brain fog with this mighty mushroom supplement.

Best Lion’s Mane Mushroom Supplement (Capsules & Powder)

Lion’s mane mushroom is a medicinal mushroom that contains many potent compounds and antioxidants to protect against cognitive decline, memory disorders and boost energy levels.

The mushroom has a long history of therapeutic effects in traditional medicine, which is just now being discovered by modern medicine. You can also find nootropic industry experts like Joe Rogan and Paul Stamets advocating its immense potential.

So, if you’re ready to jump onto the lion’s mane bandwagon, here are a few of the best options that will deliver the fantastic benefits of this equally amazing mushroom.

7 Best Lion’s Mane Supplements On The Market

  1. Mind Lab Pro
  2. Nootropics Depot Lion’s Mane 8:1 Extract
  3. Om Mushroom Superfood Lion’s Mane Organic Powder
  4. Real Mushrooms Lion’s Mane Capsules
  5. Genius Mushrooms
  6. Host Defense Lion’s Mane
  7. Double Wood Supplements Lion’s Mane Mushroom

Best Lion’s Mane Supplement Stack

It’s excellent that lion’s mane mushroom can do so much on its own but what if you put it in a stack that can do it all? Sounds too good to be true? Then why not take a look at our top recommendation for a great mushroom supplement.

Best lion’s mane stack

#1 Mind Lab Pro

An all-inclusive supplement, Mind Lab Pro is a nootropic that yields health benefits in all areas of cognition, mood, memory, focus, stress management, and energy.

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Mind Lab Pro is a nootropic brand to reckon with. Since its inception, the Opti-Nutra brand has been delivering top-tier supplements, and the Mind Lab Pro formula is no exception.

Using 500 mg of lion’s mane mushroom extract paired with other highly potent ingredients like bacopa monnieri, the brand offers one of the most comprehensive supplements for cognitive function, performance, brain fog, neurogenesis, and long-term brain health.

While lion’s mane does its work, other ingredients in Mind Lab Pro collaborate to enhance cognitive effects like mental clarity, lowered anxiety, increased motivation, and creativity.


  • Potent nutrients
  • Suitable for all ages
  • Caffeine-free
  • Science-backed ingredients
  • Offers long-term effects


  • Only available from the brand website

Best Lion’s Mane Mushroom Capsules

If you find the taste or smell of mushrooms overwhelming, your best bet is to use a capsule form. Several brands offer encapsulated lion’s mane supplements. However, not all are created equal. But here is one that beats the competition.

Best lion’s mane capsules

#2 Nootropics Depot Lion’s Mane 8:1 Extract

A mushroom nootropic with nothing other than Lion’s mane extract, Nootropics Depot is USDA organic certified, vegan friendly, and has a clean label with no added ingredients.

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Boasting a straightforward ingredient profile, Nootropics Depot Lion’s mane mushroom contains only lion’s mane extract and vegetable cellulose in its capsules.

This product features the 8:1 lion’s mane extract created from a dual solvent method using both water and ethanol. This process helps retain active compounds that are only ethanol-soluble to yield maximum potency.

Continued use will help boost the immune system, offer mental clarity, grow and repair neurons, enhance stamina and focus, eliminate brain fog, and even alleviate the effects of stress and anxiety.


  • Reasonably priced
  • Vegan friendly
  • Clean ingredient profile
  • Fights inflammation
  • Third-party tested


  • May cause some side effects

Best Lion’s Mane Mushroom Powder

Not a fan of capsules and want mushroom power in powder form? No problem! We have a product that you will love stirring into a hot or cold beverage and still get the mental and physical boost mushroom power promises.

Om Mushroom Superfood Lion's Mane Organic Powder
Best lion’s mane powder

#3 Om Mushroom Superfood Lion’s Mane Organic Powder

Harnessing the pure power of lion’s mane in powder form, Om Mushrooms offers a product that is nothing but lion’s mane, so you know you’re getting quality.

Using only ground mushrooms in their formula, Om Mushrooms is a product that does just what it promises. It gives you all the benefits of lion’s mane mushroom to support your nervous system and cognitive health.

There is nothing additional in this supplement, so all you get is 100% mushroom powder that will enhance your ability to focus, boost nerve growth, and eliminate brain fog.

So, anyone looking to see improvements in memory recall, slow down the aging process, and maintain optimal cognitive health can use this product and enjoy its sustainable, long-term effects.


  • USDA-certified organic
  • Non-GMO verified
  • Concentrated mushroom powder with no additives


  • Not as bioavailable as capsules or tablets
  • The taste may be too intense for some

Best Organic Lion’s Mane Supplement

If organic is the buzzword you’re looking for, then there are many possibilities to choose from. So, to take the guesswork out of choosing one that works, here is what we recommend as one of the most effective organic lion’s mane supplements.

Real Mushrooms Lion's Mane Capsules
Best organic product

#4 Real Mushrooms Lion’s Mane Capsules

Packing the organic goodness of lion’s mane mushrooms, Real Mushrooms uses scientifically verified contents with active compounds to deliver lasting effects.

An all-natural, highly concentrated mushroom supplement that is also organic is hard to beat. And with Real Mushrooms Organic Lion’s Mane Capsules, you get just that.

The lion’s mane in Real Mushrooms is handpicked to ensure quality and extracted using hot water to retain the benefits of its active ingredients like beta-glucans and erinacines.

This product will help boost your cognitive function, improve memory and focus, and alleviate brain fog. There are no fillers used in its formulation, and its contents are organic and third-party tested.


  • Contains 30% beta-glucan content
  • Kosher and vegan friendly
  • Non-GMO product


  • Can cause digestive side effects
  • May cause allergic reactions
  • Not effective for everyone

Best Mushroom Supplement With Lion’s Mane

Taking lion’s mane as a standalone supplement is excellent, but when you amplify its potency with other mushrooms, things can only get better. To give you results that last, we have a winning mushroom blend that is hard to pass by for any mushroom lover.

Genius Mushrooms
Best Mushroom Supplement

#5 Genius Mushrooms

For a potent punch of mushroom power, Genius Mushrooms fits the bill with its clever blend of lion’s mane, reishi, and cordyceps to give you the outcome you want.

Genius Mushrooms contain a combination of the three best medicinal mushrooms for your overall health. With the therapeutic potential of lion’s mane mushrooms, reishi, and cordyceps, and nothing else in their formula, you get exactly what mushrooms can genuinely deliver.

There are no fillers or additives to bulk up the Genius Mushrooms supplement, and everything you feel comes directly from the benefit of using three potent mushrooms.

Expect the ability to enhance mental clarity, increase focus and concentration, and reduce brain fog. Pair this with a boost of energy and resiliency to get you through your day when you use Genius Mushrooms regularly.


  • Certified organic
  • Non-GMO and grown in the USA
  • Yields long-term, sustainable effects


  • Reishi and cordyceps are only suitable for short-term use
  • The mushroom-only content requires stacking with other supplements for improved effectiveness

Best Lion’s Mane For Overall Health

Have you tried to study hard only to be hit by brain fog? Or, perhaps you are thinking of supporting brain function in an overall capacity? Whatever the reason, we have a lion’s mane product that is good for your overall health.

Host Defense Mushrooms Lion’s Mane
Best for overall health

#6 Host Defense Lion’s Mane

Incorporating the aspects of nervous support, a sharper memory, and neurogenesis, Host Defense Lion’s Mane Mushroom Capsules is a product not to be missed.

Host Defense presents a mushroom supplement that helps improve your reaction speed, observational skills, and overall cognitive health with its lion’s mane extract and freeze-dried myceliated brown rice contents.

It also promises to support nerve growth factor to assist with nerve regeneration. And you benefit from its immune-boosting properties.

Host Defense is an all-clean nootropic that will offer antioxidant support for alleviating brain fog, anxiety, and depression, with visible results in a week to two’s time.


  • Organic and sustainably cultivated ingredients
  • No added fillers


  • Not FDA approved
  • Doesn’t quite measure up to other competitors
  • Not everyone experiences benefits

Best Lion’s Mane For The Money

Looking for optimal cognition and nervous system support doesn’t have to come at a high price. You can still find nootropics that offer all this and much more within a realistic budget, and we have one for your consideration right here.

Double Wood Supplements Lion's Mane Mushroom
Best for the money

#7 Double Wood Supplements Lion’s Mane Mushroom

Double Wood Lion’s Mane Mushroom supplement is an option that offers complete nervous and cognitive support at an affordable price anyone can enjoy.

Double Wood uses USA-sourced and grown lion’s mane mushrooms to deliver an organic, non-GMO, and gluten-free product in their mushroom products.

Boasting all the health benefits of lion’s mane, this product promises to increase nerve growth factor levels, reduce brain fog and cognitive decline, and support immune system functioning.

With Double Wood lion’s mane supplements, you get the complete experience with focus, memory, mood, and clarity enhancement in a product that will fit snugly into any budget.


  • Affordable pricing
  • Gluten-free product


  • May cause some problem with digestion
  • Not as effective as other lion’s mane supplements
  • Some users don’t see a difference

How We Decide The Best Pick: What To Look For?

We know that not all lion’s mane supplements are created equal and that certain elements need to be considered before investing in a quality product.

We research the following market information before making our selection:

Supplement Type

Lion’s mane mushroom supplements are available in several different forms to suit the consumer’s individual choice. They can be purchased as extracts, tinctures, capsules, tablets, and powders.

We looked at features like ease of use and convenience for choosing the supplement types, understanding that not everyone may be comfortable with swallowing a pill. Or that others may prefer to get a kind that is easy to mix with other foods.

We recommend capsules or tablets as better options for people who follow a solid routine for using supplements and are used to taking pills. Or, for those who find the taste of lion’s mane mushroom supplements overpowering.

A powdered product is recommended for people who have difficulty swallowing pills or prefer to mix their supplement into a drink.

Liquid extracts are also easier to take and get assimilated by the body much faster.


There are many ways to gauge the effectiveness of a good nootropic. For us, word of mouth is essential, so we take a good look at what people have to report about a product.

We carefully go through customer reviews to get a feel for a particular product and what people’s experiences tell us.

Third-party testing is also a good indicator of how well a product delivers. We also consider the extraction methods of water extraction vs. alcohol.

We look into common factors using a 100% fruiting body for creating the supplement and not rely on mycelium.

Mycelium on grain refers to grain starches that provide a base for the mycelium to grow on with minimal nutrition levels (1).

The issue with this is the polysaccharides component that is hard to digest. Others like beta d glucans are important, but these are not found on the mycelium grain (2).

Instead, beta-glucans are present in the fruiting body, and we look at the levels of beta-glucans per serving.

Most manufacturers harvest the mushroom plant while still in its mycelial growth phase before developing into a mature fruiting body for production.

But products using fruiting bodies and other parts have higher nutritional and therapeutic levels as opposed to those made from mycelial cultures.

Information regarding ingredient transparency also helps us determine if the contents are dosed well for maximum efficacy.

Other considerations for efficacy include whether the product is an allergen, stimulant, and gluten-free one.


Manufacturers should avoid adding unnecessary fillers to the supplements for the purposes of purity and potency of lion’s mane mushrooms.

Lion’s mane supplements using only one or two ingredients are considered the purest forms, although users may have to stack these with other nootropic supplements to get more out of them.

We also look at third-party testing, and manufacturer certifications like USDA certified organic or a cGMP certificate.

We also look at whether the products are tested for heavy metals.


We understand that different users work with different budgets when looking at their healthcare options. For this reason, we try to offer a variety of budget options and products so that everyone can have a figure that works for them.

Our selection of lion’s mane mushroom supplements comes with varying price points to make them suitable for different budgets.


Taking lion’s mane supplements are a great way to invest in your cognitive health with their many bioactive compounds and beta-glucans.

Its medicinal value includes benefits like immune system support, protecting and growing neurons, eliminating brain fog, and antioxidant activity, to name a few (3).

While both the mycelium and fruiting bodies contain bioactive compounds, the fruiting body has a higher medicinal value.

That is why we recommend Mind Lab Pro for anyone who wants to include this incredible mushroom into their daily regimen. Mind Lab Pro provides an ideal balance of nootropic ingredients in optimal doses to deliver continual, long-term results.

It is suitable for those new to supplements as it is a preformulated stack that takes the guesswork out of stacking. It is also equally well cut out for seasoned users who want to keep up their brain health and performance.

So anyone with an energetic or busy lifestyle would surely appreciate what this nootropic has to offer.