Several popular racetams offer a plethora of nootropic effects, but some are weaker than others.
Furthermore, each of the racetam compounds provides unique benefits because of different mechanisms. Pramiracetam provides benefits, including improved focus, memory, and cerebral blood flow.
However, before we look at those beneficial features, it is good to look at what it is and how it produces the desired effects.
What is Pramiracetam?
Pramiracetam, or N-[2-[di(propan-2-yl) amino] ethyl]-2-(2-oxopyrrolidin-1-yl) acetamide, is a racetam drug, which is a family of nootropics that includes piracetam and aniracetam. Pramiracetam was first synthesized in 1979 by the Parke-Davis pharmaceutical company.
It was developed as a potential treatment option for those suffering with brain injuries, central nervous system disorders, and neurodegenerative disorders, and Parke-Davis marketed the substance as Pramistar. It is also used as an orphan drug for depression and other mental health conditions.
Additionally, pramiracetam offers more potent effects, and some users report an experience 30 to 100 times stronger than piracetam benefits.
A review of the information online shows that the most common purposes for this specific nootropic are improved concentration, information processing, and brain membrane fluidity.
How Does Pramiracetam Work In The Brain?
Pramiracetam has many avenues in its mechanism of action that help to provide the results. First, it increases High-Affinity Choline Uptake (HACU).
High-Affinity Choline Uptake in the hippocampus portion of the brain has several crucial responsibilities. First, this boosts acetylcholine levels in the brain. In turn, it offers cognitive-enhancing effects, including improved memory function.
In addition, pramiracetam acts on the neurotransmitter acetylcholine (ACh) and may also influence other neurotransmitters, including dopamine and serotonin.
The impact on the neurotransmitter dopamine can offer better mood, reduced stress and anxiety, and natural energy. Acetylcholine can help with cognitive function and neuroplasticity.
Finally, pramiracetam also improved cerebral blood flow by increasing the brain’s nitric oxide (NO) activity. Nitric oxide also relaxes blood vessels and allows more oxygen and nutrients to brain cells, improving cognition and learning ability.
What Are The Benefits of Pramiracetam?
Pramiracetam offers a wide variety of benefits to cognition, many of which users report as the best option for specific desired results.
The improvement of working memory is possibly the most sought-after purpose for those who use pramiracetam. Research studies on this aspect show that the nootropic can impact memory formation several ways (1).
Pramiracetam impacts meta-memory performance, which accounts for the ability to process existing memories and formulate new memories. The research team in one study found that the impact on memory was significant enough that it might be a preventative treatment for memory decline or amnesia.
Some research studies examine participants in memory training. The results show that memory was improved, and there was less memory loss in those who took pramiracetam than those in memory training and not taking pramiracetam. One feature of pramiracetam that improves memory loss is the improvement of recall and retention.
Finally, pramiracetam also positively impacts information processes that could contribute to better memory and recollection abilities.
As a result, many experts are excited about Pramiracetam as a tool to help with memory loss, amnesia, and dementia, especially when combined with traditional prescription drugs.
Has Neuroprotective Effects
The reduction of memory loss and potential treatment of dementia is also related to the neuroprotective features of nootropics, including pramiracetam.
Human studies show that pramiracetam offers the ability to ward off cognitive degeneration and reduce the rate of decline in cognitive function (2).
Pramiracetam is a common choice for preventing poor cognition caused by age. This makes it yet another tool in the arsenal for those looking to stay mentally fit throughout an entire lifetime.
While this effect may be more attractive for middle-aged or older people, young people can also benefit from the use of pramiracetam.
The neuroprotective properties may even be enough to improve brain function in those that already have reduced cell signaling and neuron activity.
So while it is normal for aging people to experience, pramiracetam supplements may be suitable for reducing the impact that has already occurred.
Finally, these nootropic effects may be good for overall cognition and may help to keep the mind sharp for longer. The increase in acetylcholine can help reduce the impact of decline and offer cognitive enhancement for otherwise healthy adults.
Helps To Recover From Brain Injuries
Brain trauma or brain injury can impact every aspect of cognition, well-being, and mental health. Evidence shows that pramiracetam can positively impact brain health that could help reduce or eliminate the symptoms associated with brain injury or stroke.
Part of the reason for these effects is the improvement of blood circulation. Brains that receive more nutrients are likely to be healthier and, therefore, more likely to adequately recover from an injury or other form of trauma.
Another positive effect that pramiracetam has on the brain is related to growth and plasticity. When our brain has more plasticity, it is more likely to adjust to big and small changes.
An injured brain cannot recover rapidly or effectively if the brain cannot adapt to the unique situation. Pramiracetam can force this process along to make a recovery faster (3).
Finally, racetam nootropics also work for many aspects of cognition that could be impacted by trauma or injury to the brain.
Since pramiracetam is good for learning, memory, and other cognitive processes, it can help provide stimulation to brain mechanisms, reducing the impact of the injury on the ability to think and process information with accuracy.
Pramiracetam also offers some beneficial results regarding alertness, focus, concentration, wakefulness, and learning. For example, research shows that it can provide the user with a sense of calm focus that can be highly beneficial during the workday or studying.
Like some other racetams, pramiracetam offers some stimulatory effects, which helps to boost energy and improve focus and creativity.
This can help you stay on task and reduce the distractions and brain fog you experience during the workday. The science behind the evidence has been referenced in talks that it is a potential treatment option for people suffering ADHD or dyslexia.
Animal studies show us it also improves learning capacity, which the improvement of alertness may cause (4). When we are more focused and alert, we are more likely to learn and recall the information.
These improvements in learning make racetam nootropics a popular choice with college students looking to improve their study habits.
Finally, this nootropic result can also improve productivity because a user will be more alert and focused. Thus, not only can nootropics help enhance the work that a person can complete, but pramiracetam may also improve the quality of that work.
Treats Degenerative Disorders
Research shows that the best racetams and related nootropics, including pramiracetam, offer potential in treating degenerative disorders and diseases. There is evidence that it could help with Alzheimer’s disease and other forms of dementia (5).
In fact, in some parts of the world, including Europe, pramiracetam is a prescription drug used for Alzheimer’s disease and other neurological disorders.
Animal studies on rats show that this nootropic can offer measurable improvements to different aspects of cognition.
It is likely caused by the influence on various neurotransmitters utilized for proper thinking and analysis. A healthy, properly functioning brain requires a balance of brain chemicals that support a positive choline supply.
The effect it has on cerebrovascular insufficiency could also be beneficial for a positive result in those suffering from degenerative disorders. This is because it offers better nutrition to the brain that can help to provide the resources for proper function.
While the studies are still limited, the mechanisms of pramiracetam could be a potential treatment for degenerative health conditions. In addition, more and more patients are adding nootropics to their traditional drug routine to boost the impact on their disorder.
Promotes Social Fluency
A lot of individuals find that pramiracetam’s nootropic effects also improve their social fluency. Many distinct features may contribute to this, including an impact on GABA that can reduce stress and inhibitions, especially for social anxiety (6).
In addition, the impact on other aspects of mental health and well-being. For example, this can lead to more comfort in social situations and motivation to participate in social experiences.
Furthermore, like other nootropics, it also improves focus, which can help move a conversation along with intriguing and creative thoughts. The listening skills can also be improved because of the sense of focus that pramiracetam substances can provide.
Finally, the mild stimulant effects also allow thoughts to move readily through the mind. This can make the conversation more fluid and natural.
These effects combined make pramiracetam one of the best nootropics to use for social interaction, especially interactions that require significant focusing abilities.
How To Take Pramiracetam?
The pramiracetam nootropic is most often found in powder form, but also it can be placed into capsules for convenience and pre-made doses.
However, it is crucial to take an effective dose without going overboard because it improves the efficacy of nootropic supplements.
Pramiracetam dosages range from 250 to 400 mg, which can be taken up to three times per day. The standard daily intake is 1200 mg.
It is best to take the first dose early in the morning and avoid taking doses too late in the day because that can cause insomnia and other sleep disturbances.
Also, be sure to start with the lowest dosage required to achieve the desired effects. Most people start with a pramiracetam dosage as low as 100 mg and then gradually increase the dose or add in second and third doses until you reach the desired effect.
Since pramiracetam is fat-soluble, it is absorbed into the bloodstream via fatty acids. For a better effect, take your supplement with healthy fats like olive oil or fish oil. Doing this can increase the bioavailability and absorption rate.
What is The Half-life?
Pramiracetam has a reasonably long half-life from 4.5 to 6.5 hours. However, the onset is rapid, and most people will feel the effects in the first 30 minutes to an hour.
This is especially true when taken with fats. The duration will last anywhere from four to six hours depending on tolerance, dose, and whether it is taken with another supplement or drug.
The peak is usually felt between an hour and an hour and a half.
Many people prefer to stack their pramiracetam with other nootropics to improve upon the beneficial result.
There are a few nootropics that are commonly part of a stack.
Pramiracetam and Choline Stack
Combining pramiracetam with a choline supplement source can offer beneficial action on the body and mind.
Both Alpha-GPC and CDP Choline can enhance the effects of Pramiracetam and reduce some of the common side effects, including headaches.
Our recommendation for an effective dose is 250-500 mg of Pramiracetam and 250-300 mg choline. This combination can be taken 1 to three times daily.
Pramiracetam and Aniracetam Stack
Stacking pramiracetam with Aniracetam can improve the effect on mood and stress. It is also suitable for social interactions and cognitive performance.
Combining these two nootropics provides a complete supplement for anyone looking to improve their cognition, energy level, and overall performance.
For this combination, take 250 to 350 mg Pramiracetam with 500 to 750 mg of Aniracetam 1 to 2 times per day. You may also want to add a choline supplement for well-rounded effects.
Pramiracetam and Oxiracetam Stack
Oxiracetam is a superb choice for stacking because it boosts energy levels and alertness.
This can be great for combating mental fatigue and its impact on the body since it may prolong those effects, especially when taken regularly.
Take this stack up to two times per day, starting with 250 to 300 mg Pramiracetam and 750 to 1000 mg Oxiracetam. Then, again, you can add choline to add to the power of the combination.
Pramiracetam and Noopept Stack
If your primary goal is to improve memory, then you should consider adding Noopept to your routine.
This combination is excellent for improving the accessibility of memories and the storage of information. It also enhances overall cognition.
This stack should be taken 1 to 2 times daily, and you can use 250 to 300 mg Pramiracetam with 20 mg Noopept.
Does Pramiracetam Have Side Effects?
This supplement is safe, but it can cause some side effects that you may want to be aware of. The most common side effect is a headache.
In addition, you may find other side effects like nausea, dizziness, anxiety, and difficulty sleeping. Some people also find that it blunts their emotions.
You should also be cautious when taking it if you are currently taking other drugs because unexpected adverse reactions can occur. This is especially true with anti-depressants and prescription stimulants.
Finally, tolerance can occur with regular use, meaning that it will take more to achieve the same effect. So it is best to cycle the supplement 5 days on two days off or 4 months on 1 month off.
Where To Buy Pramiracetam?
Pramiracetam is sold as a dietary supplement in the United States, and you can find it available in most online stores that specialize in nootropics.
However, you must find a reputable vendor to ensure your safety when buying any nootropic or supplement.
Look no further. The most potent pramiracetam from PureRawz is always lab-tested, rapidly shipped, and loved by those in the nootropic community.
Pramiracetam is a fantastic nootropic for better memory and focus. It can also be good for mental health and offers neuroprotective abilities.
However, it will not achieve these claims if you do not take it with some form of fat, which can also cause some disturbing side effects.
Still, it can be a significant addition to your routine and help to boost your cognition and related functions.
It is a popular choice among students and hard-working individuals because of the wide variety of beneficial effects.