Phenylpiracetam is a giant among synthetic nootropics, given its higher potency and strength among this class of smart drugs.
It is a powerful stimulant used to improve memory, cognition, mood, and physical function. Given its quick-setting effects and low frequency of adverse effects, it is a popular choice among different demographics.
So, how well does science back its potency and mechanisms for humans?
- What is Phenylpiracetam?
- How Does Phenylpiracetam Work In The Brain?
- What Are The Benefits of Phenylpiracetam?
- How To Take Phenylpiracetam
- What Are The Side Effects of Phenylpiracetam?
- Where To Buy Phenylpiracetam?
What is Phenylpiracetam?
Phenylpiracetam has an added phenyl group to the original chemical structure derived from piracetam, the original nootropic drug.
This makes it a synthetic nootropic drug of the racetam family that does everything that racetams do and some more.
It features the chemical structure 2-oxo-4-phenylpyrrolidin-1-yl-acetamide, that when compared to piracetam, the phenyl group attached appears to have superior neuroprotective properties.
Also, it seems better on the psychostimulatory front, quite similar to Adderall.
The phenyl group increases the oral bioavailability of phenylpiracetam and its ability to cross the blood-brain barrier (1).
Much of the research on phenylpiracetam shows that it debilitates the symptoms and rate of cognitive decline in animal studies and humans. Most of the involved studies have used the drug for over a month to see its full effects.
However, cognitive enhancement is best observed in people already suffering from cognitive decline, epilepsy, or organic brain lesions (2).
Some evidence also reports the potential of phenylpiracetam to improve physical performance. However, clinical trials in this area have involved elderly individuals who have suffered a stroke and not those without cognitive impairment.
Research on otherwise healthy people is limited, so its cognitive-enhancing effects on this demographic are hard to establish.
How Does Phenylpiracetam Work In The Brain?
Belonging to the racetam family of drugs, phenylpiracetam acts as a central nervous system stimulant and nootropic agent.
While it is now used for many nootropic benefits, its initial purpose was to allow cosmonauts to manage the prolonged stress of working in space flight.
Its creation is credited to Russia, where people don’t need a prescription to buy phenylpiracetam for treating medical issues. However, in the U.S., it is available as a dietary supplement but is not regulated by the FDA.
The nootropic drug also goes under brand names and is known as Phenotropil, Carphedon. Many of its functions are involved in stimulating the production of various neurotransmitters.
Studies suggest that phenylpiracetam may exhibit a direct affinity for nicotinic cholinergic receptors with a potential to increase the level of NMDA – glutamate receptors.
In addition, evidence associates its working mechanism as a dopamine reuptake inhibitor to boost dopamine levels for improving mood and motivation.
Researchers also link it to increasing the growth of protein brain-derived neurotrophic factors to promote the creation and development of brain cells. And it increases beta wave activity responsible for cognitive processes like alertness and mental coordination.
Once ingested, the drug gets absorbed quickly in the digestive system, from where it gets distributed to other organs and tissues. It can also cross the blood-brain barrier to perform various aspects of cognitive function in the brain.
What Are The Benefits of Phenylpiracetam?
Phenylpiracetam presents many benefits making it a highly coveted drug for brain health and cognitive function.
Its action is amplified with its phenyl compound where it is believed to help the mind and body in the following ways:
Reduces Anxiety and Depression
Phenylpiracetam shows the potential to lower anxiety and depression in animal research. For example, animal studies show that it reduced such behavior symptoms with antidepressant effects in mice and rats with drug-induced psychosis.
Some evidence from human studies also shows phenylpiracetam to present an antidepressant effect in people with brain damage (3).
The calming properties of this drug may also be given its ability to increase the number of GABA receptors. Since GABA is effective as a relaxant and anxiety reliever, it slows brainwaves and has an anti-stimulant effect.
Like other nootropics, phenylpiracetam is a potential treatment to improve memory and cognition and make it sharper. One animal study in this area shows that the drug presented increased dopamine receptors in rats with memory loss.
Dopamine is a neurotransmitter produced by brain cells responsible for memory, attention, motivation, and reward.
Evidence confirms that increases in dopamine levels resolve working memory actions like planning, reasoning, and problem-solving.
Brain Protection and Recovery
Phenylpiracetam is also used for neuroprotection and recovery. Studies show phenylpiracetam to increase the activity of acetylcholine receptors that may also stimulate the development of new synapses between nerve cells.
In this way, it is beneficial for neuroplasticity and neuroregeneration.
Some research looks at the drug’s ability to increase cerebral blood flow, oxygen, and glucose consumption, especially in people with mental impairment.
Boosts Energy, Attention, and Focus
Phenylpiracetam is also an excellent candidate to boost productivity as it claims to improve energy, attention, and focus.
Research shows it to yield similar Adderall effects, delivering a clean sense of stimulation without jitters and crashes. While it induces the central nervous system, the phenyl molecule does not cause stimulant effects like an amphetamine.
Using phenylpiracetam makes thinking more precise and fluid, where users report finding it easier to focus and absorb information.
Once again, studies with animals confirm the mechanisms of phenylpiracetam to have an energizing effect by increasing locomotor activity (4).
Phenylpiracetam can also help with sleep deprivation which is the right way to boost energy, attention, and focus. Testing on rats indicates its ability to manage sleeplessness and improve motivation better than methylphenidate and amphetamine.
People who have used it to improve their sleep patterns review its effects similar to modafinil, lowering fatigue and improving productivity.
Affects The Immune System
Inflammation is the result of the immune system’s response to harmful stimulation.
In this way, it is a good thing but turns into a health concern when the immune system overreacts and starts attacking healthy tissues within the body.
Animal studies show phenylpiracetam to possess antioxidant properties that can reduce inflammation. One such study investigated the effect of phenotropil on cytokine levels in male rats.
Reduces Weight Gain
Phenylpiracetam may also be a viable treatment for managing weight problems. The effects of phenylpiracetam on body weight were observed in an animal study where obese rats were administered phenylpiracetam for 8-12 weeks.
Findings from the study showed that it presented the effects of reducing plasma glucose and leptin concentration.
This gives the outcome that phenylpiracetam reduces body weight and improves adaptation to hyperglycemia without triggering locomotor activity (5).
How To Take Phenylpiracetam
Phenylpiracetam is available in different types of capsules, tablets, and even in powder form. This is a powerful option compared to other similar drugs, so phenylpiracetam dosage is usually quite effective even when low.
While capsules and tablets are the more popular forms of oral supplementation, the powder is used for sublingual administration. That being said, some racetams can deplete choline as they complete their various processes.
For this reason, it is common to add a choline dose alongside phenylpiracetam to ensure that the brain provides the acetylcholine it needs to improve its overall effectiveness and help prevent headaches.
You can take phenylpiracetam on an empty stomach for optimal absorption.
Another suggestion is to cycle it with other nootropics to prevent tolerance. Or use it for exacting activities like a big project, test, or exam demanding attention and focus for long hours.
Phenylpiracetam is taken at a dosage of 100-200 mg at a time. You can take this dose 2-3 times daily, totaling 200-600 mg per day.
For many people, the lower dosage range seems to work well enough. However, the optimal dosage has not been established yet.
Because it is more potent than piracetam, it may be a good idea to start with lower phenylpiracetam doses and then build your way up.
However, its contents are up to 60 times more concentrated than piracetam, its parent molecule, so you only need a little to get the desired effects.
Most users space out their phenylpiracetam dosage throughout the day. At the same time, research indicates that users can develop a tolerance to phenylpiracetam, so it is suggested to take this drug occasionally instead of daily.
Also, since an optimal dose has not been established, users are advised to stay within the recommended dosages.
What Is The Half-life?
Phenylpiracetam is a fast-acting substance that gets detected in the brain within 30 minutes of ingestion. It has a half-life of around 3-5 hours, with its effects lasting about 6-10 hours.
It takes phenylpiracetam about 30 hours to entirely leave the system, so it’s best not to use it every day.
Nootropic stacks are a popular way to enhance the performance of any given nootropics by combining them with others to get optimal results.
The practice helps in either achieving improved synergy between different nootropics, preventing side effects of single nootropics, or improving the health benefits that nootropics yield when used together.
Phenylpiracetam can also be stacked safely with other nootropics, among which popular choices include alpha-GPC, choline, and sulbutiamine.
Phenylpiracetam and Choline Stack
This is a popular combination to potentiate effects and ward off acetylcholine headaches, an occasional side effect of racetam use.
Experts suggest trying this stack without including any other nootropics in the mix and starting with the lowest dose to give the desired outcome.
The ideal ratio to start with is suggested at 100 mg of phenylpiracetam and 250 mg of choline, preferably citicoline.
Phenylpiracetam and Noopept Stack
These are two very potent piracetam derivatives requiring low dosages to experience positive effects.
While Noopept isn’t technically a racetam molecule as it lacks a 2-oxo-pyrrolidone structural core, it is commonly grouped with racetams because of yielding several similar effects.
Studies show the two compounds to create synergistic cognitive-enhancing effects like promoting energy and mental functions.
This stack is often used for improving focus for prolonged durations without developing mental fatigue.
A starter stack using the two substances could use 10 mg Noopept, 200 mg phenylpiracetam, and 300 mg alpha GPC as the stack’s choline source.
Phenylpiracetam and Phenibut Stack
Evidence shows stacking these two substances together promotes stress-relief, mental calmness, and improved focus.
Phenibut is linked to reducing feelings of anxiety without causing sedation of the CNS at low doses.
The thing to watch out for is that both are substances that users may develop a tolerance for quickly. Therefore, neither of the two nootropics should be taken continuously or at a higher dose.
A starter recommendation will look to include 100 mg phenylpiracetam with 500 mg phenibut.
What Are The Side Effects of Phenylpiracetam?
Phenylpiracetam can present some side effects, many of which tend to be mild and temporary. Since the drug itself is relatively well-tolerated, the risk of experiencing these side effects is relatively low.
Most nootropics users report experiencing anxiety, headaches, brain fog, nausea, fatigue, some insomnia, and mood changes. There have also been reports of difficulty sleeping, depression, and emotional instability.
To reduce the risk of these side effects, it is crucial to use phenylpiracetam responsibly.
The one consideration with phenylpiracetam consumption is that it is easy to develop tolerance to this substance. As such, many users advocate cycling phenylpiracetam instead of using it continuously.
Anyone who experiences any side effects should discontinue its use immediately.
Where To Buy Phenylpiracetam?
Phenylpiracetam is available for purchase as a non-prescription option in stores and online through various retailers and vendors.
Different sellers carry different brands of this drug, and it’s essential to check these for quality and efficacy.
Also, look for user testimonials, customer reviews, and any certifications that the manufacturers can provide.
Piracetam packs a powerful punch when it comes to boosting cognitive function. It is among the more well-researched options with benefits like enhanced brain functions, improved energy levels, and stress reduction among nootropic supplements.
With phenylpiracetam, this potency is multiplied, and users get complete support for memory, cognition, mood, learning, mental clarity, and overall improved performance levels.
Phenylpiracetam also sustains popularity because it is one of the most powerful in the racetam class of drugs, requiring significantly lower doses when compared to the older and less powerful nootropics.
Combining these features rounds off a complete nootropic, making phenylpiracetam an interesting supplement for comprehensive brain support with relatively low side effects when used responsively.