Noopept vs. Piracetam: Differences and What’s Better

Noopept and piracetam are two of the most effective nootropic compounds, but what are the outcomes?

Noopept vs. Piracetam: Differences and What’s Better

While both piracetam and noopept supplements offer benefits to cognitive performance, they provide unique properties and results. Therefore, depending on the reason, you want a nootropic, one or the other may be an excellent choice.

For that reason, it is good to be aware of the different nootropic effects of each one and the potential downsides that the substances may present.

This article covers every aspect of noopept vs piracetam to help you decide between the two smart drugs.


    What’s The Difference Between Noopept and Piracetam?

    It is good to understand the different benefits and disadvantages of the two compounds to understand the differences between noopept and piracetam.

    This is because each nootropic acts on the brain and body in unique ways responsible for the individual effects.


    Noopept, or n-phenylacetyl-l-prolyglycine ethyl ester, was developed in the 1990s as a potential treatment option for Alzheimer’s disease and other forms of dementia.

    It works by increasing the brain-derived neurotrophic factor (BDNF) levels in the brain, promoting healthy brain cells.

    Since noopept readily crosses the blood-brain barrier, it has improved efficacy and bioavailability compared with many other nootropics. It also modulates the levels of the neurotransmitters glutamate receptors and acetylcholine.

    The mechanism of noopept makes it a popular choice for students, night shift workers, and those looking to reduce stress and fatigue.

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    Noopept Benefits

    Noopept offers a wide range of benefits. First, it can improve mental performance and overall cognition. This is especially true about its impact on memory and learning because the main effects of noopept help with information processing (1).

    Also, noopept can improve memory and may even help to recover distant memories that once were lost.

    Furthermore, many studies show that noopept is an excellent choice for preventing age-related cognitive decline because of its powerful neuroprotective benefits.

    These benefits combine with the impact on memory enough to possibly prevent or treat Alzheimer’s and the impact of brain injuries. It also improves overall brain health and enhances neuroplasticity necessary for brain function (2).

    Noopept also has a positive effect on mood and may help to reduce the risk of developing depression, anxiety, and other mental health conditions. In addition, there is also evidence that shows that noopept can help reduce stress levels and the associated brain fog (3).

    Noopept is great for overall well-being and typically intended to increase functions of brain chemicals that help with emotional balance.

    The compound may help with sleep function as well, which can drastically improve overall health and cognition. Plus, the strong results occur immediately to allow a user to achieve their nootropic goals.

    Finally, noopept may help improve your focus and concentration by reducing negative thoughts and improving your mental processing ability.

    These effects are likely related to improving mood and memory, which can help elevate your motivation and productivity.

    Disadvantages of Noopept

    The most common disadvantage of noopept is the increased tolerance, which means it will be required to use higher dosages to achieve the same results over time.

    Because of this, it is best to cycle a noopept supplement by taking 2 days off for every 5 days of use.


    Piracetam, or 2-oxo-1-pyrrolidine-acetamide, was the first nootropic of the racetam class of drugs and was synthesized in 1964.

    It is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA) but works differently. The mechanism offers effects on the mind and thinking.

    It also affects the AMPA and NMDA receptors essential for cognitive function, particularly learning and memory. In fact, in some countries, piracetam is prescribed for learning disorders, including dyslexia.

    Thus, piracetam works for cognitive enhancement and brain health, making it a popular and potent nootropic choice over 50 years after being created.

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    Piracetam Benefits

    Piracetam has a positive impact on cognitive ability that can improve memory recall and learning. In addition, it influences different processes that can help with neurotransmission and signaling (4). This helps with brain performance like other racetams but also has some additional benefits.

    Piracetam may help with attention span and concentration, and these effects are likely responsible for piracetam’s popularity. This nootropic can improve blood flow and prevent blood clotting.

    When blood flow is better, more nutrients and oxygen make it to the brain, and cognition is enhanced. This could boost mental energy as well.

    It is the desired effect of cognitive enhancers because it can help with processing speed and mental clarity. It may also help with a wide variety of cognitive functions because it improves how quickly the mind can process information and support cognition.

    Finally, this effect may help to keep you alert and effective even when tired or stressed. Piracetam also helps with verbal fluency. The reasons for this are not fully understood, but it seems to help with mild cognitive disorders or age-related decline (5).

    Older people sometimes have difficulty talking or processing information, and piracetam may reduce this type of impact on brain health.

    Compared with other smart drugs, piracetam provides nootropic effects that are unique. For example, it can help children and students with dyslexia and can even reduce pain caused by inflammation (6). It also helps with symptoms of myoclonus epilepsy and reduces seizure activity in the brain.

    Disadvantages of Piracetam

    The primary downside to piracetam use is related to the action similar to prescription drug stimulants.

    It can cause excessive stimulatory action and lead to side effects like insomnia, dizziness, hyperactivity, poor mood, and other undesirable effects.

    Noopept or Piracetam: The Comparison

    It is crucial to look at several aspects of both supplements to do a proper noopept vs piracetam comparison.

    This ensures that everything is considered before deciding which substance might be better for the nootropic results.

    Mechanisms of Action

    Noopept and piracetam have similar effects, but the most significant difference in the benefits comes from each nootropic’s unique mechanisms of action.

    While noopept primarily works on BDNF, piracetam does more for acetylcholine in the brain. So while both nootropics support choline, piracetam influences the acetylcholine receptors more.

    Because piracetam works on neurotransmitter activity at the receptor, it does not have long-lasting beneficial effects compared with noopept. This helps to make noopept more potent than piracetam when it comes to long-term use.

    Still, piracetam can be a superb choice, but the effectiveness may decrease over time if you do not stack it with other nootropics.


    The primary purpose of noopept vs piracetam is definitely something to keep in mind because everyone seeks nootropics for different reasons.

    Both nootropics can help improve focus and concentration, but piracetam has an edge with those effects because it acts more like traditional stimulants. This can be great for productivity, motivation, and it may slightly boost mood.

    However, for most of the other purposes, noopept is the more potent nootropic. For example, it is better for memory and can work well enough to recover a long-lost memory in some people.

    Noopept is also more powerful than piracetam when it comes to the impact on mood, and it can even be beneficial for depression and anxiety. Finally, it also offers potent neuroprotective benefits.

    On the other hand, piracetam may offer some additional benefits like improved learning and reduced inflammation, but in nootropic effects, it does not have the potency of noopept.


    Noopept vs piracetam dosages differs a lot to get the desired effects. Noopept requires a low dose when compared with the recommended dosages for piracetam. In fact, the dosage difference is profound.

    Piracetam requires doses between 800 and 2400 mg, which are substantial doses, especially compared to noopept dosages.

    Noopept doses may present effects with as little as 5 to 10 mg, and high doses are in the 30 mg range. Therefore, noopept is better because 50 to 100 times less of the nootropic has to be ingested for desired effects.

    However, these differences do not matter much for some people since they do not mind taking a gram or two of piracetam.

    Side Effects

    Both noopept and piracetam are considered safe and well-tolerated for healthy people. However, some people may experience at least one side effect. The severity of side effects often increases with dose as well.

    Piracetam’s most common side effects are insomnia, nervousness, hyperactivity, weight gain, and diarrhea. It is also best to avoid piracetam late in the day to avoid sleep disturbances.

    Most of the common side effects for noopept are similar, with the addition of headaches and irritability. The most severe side effects of both are related to mood changes and over-stimulation.

    Both nootropics should be avoided by pregnant or nursing women and those who have high blood pressure. Mixing nootropics can also increase the frequency and severity of side effect symptoms.

    Therefore, neither nootropic is preferred when discussing side effects, and the result will differ for every individual.


    When comparing noopept vs piracetam for the same benefits, you probably want to compare the overall price per dose.

    The good news is that both nootropics are affordable. So, for the review of price, we compared the price per dose of both nootropics.

    The price per dose of noopept ranges from about $0.30 to $0.75 per dose. This is very affordable compared to various other nootropics.

    On the other hand, piracetam ranges from around $0.50 to $1 and more per dose if you get capsules. So this clearly benefits noopept at the top end of the cost.

    Which Nootropic Is Better To Choose?

    After comparing the effects, price, dose, and all other factors, noopept is the better nootropic choice overall.

    This is because it has more potent effects and is better for overall cognitive function and mental health. It is also a splendid choice for preventing rapid age-related decline, reducing anxiety, and improving memory.

    However, if you are looking to boost cognitive energy, focus, and verbal fluency, then you may prefer piracetam. It is also beneficial for memory and learning and is an excellent choice for stacking with nootropics that act on acetylcholine.

    Both nootropics have gained popularity in the nootropics community for a reason, which is that they work. So it is hard to go wrong with both noopept and piracetam.