Coluracetam Review: Benefits, Dosage, and Side Effects

Coluracetam is one of the newest additions to the racetam class and is known for its potent cognitive benefits.

Coluracetam Review: Benefits, Dosage, and Side Effects

Most of us have those days where we feel like time is leaving our mind behind. Coluracetam is a nootropic that may improve your mood and brain function enough to eliminate those days when you feel down and slow.

Coluracetam is also a popular choice for students and older people who want to keep their memory in good shape.

It works in a few different ways to provide those effects, but what is it, and what makes it different from other racetams?

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What is Coluracetam?

Coluracetam, or MKC-231, is a member of the racetam family first synthesized in 2005 by the Mitsubishi Tanabe Pharma Corporation, a pharmaceutical company.

This makes it one of the newest racetam compounds. It was originally developed as a nootropic compound that was a potential treatment option for Alzheimer’s disease and other forms of dementia.

However, the patent was later sold to Braincells Inc. as they wanted to research the nootropic supplement to treat Major Depressive Disorder (MDD).

Coluracetam is more potent than other racetams, including the original piracetam. It is similar in structure to other nootropics in the racetams family because it has a pyrrolidine nucleus at its core.

In addition to boosting cognition and memory, coluracetam has shown great potential for improving mood and symptoms of depression and anxiety. It is also unique because it is known for enhancing vision.

Coluracetam remains unregulated in the US and is only sold as a dietary supplement. Some countries, including Canada and the UK, require a prescription to obtain the nootropic drug.

How Does Coluracetam Work In The Brain?

While it works in a few different ways, the primary effects of coluracetam are rooted in its action as a choline uptake enhancer.

This means that it enhances high-affinity choline uptake (HACU), thereby increasing the levels of the neurotransmitter acetylcholine, which is associated with memory and cognition.

The effect on the neurotransmitter acetylcholine is different from other nootropics that influence increased production. This is because it works with acetylcholine synthesis and conversion.

Therefore, it indirectly affects acetylcholine levels and the concentration of acetylcholine in the brain.

Several studies also show that coluracetam acts on AMPA receptors as well. This could offer some benefits of stimulants and related drugs without causing some of the nasty side effects.

In addition, this process could be responsible for the anti-anxiety coluracetam features.

What Are The Benefits of Coluracetam?

Coluracetam holds several beneficial properties that make it a popular addition to a choline supplement or nootropic stack.

Improves Memory and Learning

There is significant evidence that coluracetam is beneficial in improving memory and learning.

One study showed that mice had improved working memory deficits, and there is reason to believe that these coluracetam effects could also help humans (1).

Coluracetam’s effect has a profound impact on short-term memory and comprehension. It improves the ability to memorize information and can even help a person free recall and develop memories that they thought were lost.

While more animal or human studies need to be completed, there may also be positive effects for long-term memory.

In addition to these benefits, coluracetam works for learning ability and information processing at a higher speed. It also improves learning speed, free recall abilities, and the retention of information.

It can make it easier to focus on the task at hand, making it more likely to be correctly stored within the brain for future access.

Helps With Mental Disabilities

Clinical trials show that coluracetam may help people with mental disabilities. For example, people who have Alzheimer’s disease may see an improvement in their cognition.

This may also be true for other forms of dementia, average age-related cognitive decline, an imbalance in brain chemistry, and neurotransmitters including dopamine and serotonin, required for emotional balance and mental health (2).

Coluracetam can also help those with learning disabilities. Studies show that the ingestion of coluracetam helped with learning impairment. It also improved spatial learning and overall cognitive performance.

Finally, coluracetam may also be suitable for schizophrenia. This is because schizophrenia hinders hippocampal acetylcholine production.

The supplement can balance the levels of acetylcholine to reduce the frequency and severity of schizophrenic symptoms. This may even be beneficial as a protective effect against potential disabilities in healthy people.

Relieves Symptoms of Depression and Anxiety

Before Braincells Inc. owned the patent, the benefits that coluracetam has for depression and anxiety were unknown.

However, plenty of evidence now shows that it may be beneficial for reducing anxiety levels and improving treatment-resistant depression (3).

The effect that coluracetam has on mood and depressive disorders could be profound enough to help with Major Depressive Disorder. In addition, it is a reliable mood lifter that may be able to treat depression properly.

It may even boost energy levels and motivation in those suffering from anxiety and depression, which could also benefit the symptoms.

Since coluracetam seems to influence the neural transmission of serotonin levels, it could be a great way to treat the underlying causes of Generalized Anxiety Disorder as well.

In addition, since anxiety and depression often go hand-in-hand, this could be an option for people who have not had success with a more traditional prescription drug and even offers some acute effects. In contrast, antidepressants can take weeks to work at all.

Provides Long-term Cognition Improvement

A lot of synthetic nootropics only work short-term to improve cognitive function. Coluracetam, however, offers long-lasting cognitive improvement.

Moreover, some people claim that their brain fog has been permanently lifted after repeated administration of the dietary supplement (4).

These long-term effects are likely caused by the high-affinity choline uptake (HACU) that remains improved for a prolonged period after supplementation with coluracetam.

The higher levels of acetylcholine last much longer than they do with the usual choline supplement. Coluracetam increased the period to improve memory as well.

One clinical trial shows that coluracetam works like neurogenesis stimulating compounds. The mechanism of action benefits brain plasticity, the health of nerve cells and neurons, neuronal cultures, and brain receptors (5).

This means that coluracetam addresses cognitive problems via neuroscience, which has better long-term results than merely addressing acute symptoms.

May Enhance Vision

One more unquiet benefit of coluracetam is the effect it has on vision. It can provide enhanced vision, make shapes and colors more defined. This supplement may increase shape recognition and positively affect color vision, optical awareness, and vividness.

While there are few human studies on these vision benefits, there is reason to believe that coluracetam could help prevent age-related vision problems and even avoid eyesight-related illnesses like glaucoma.

The enhanced vision also comes with some other benefits. For example, when our vision is better, we are less likely to suffer from eye fatigue. Some people even find it easier to maintain alertness and focus when their vision quality is improved upon.

How To Take Coluracetam?

Coluracetam is usually sold as either a powder or in capsules. It is fat-soluble, so taking it with a meal high in healthy fat can benefit absorption and bioavailability.

In addition, it can be taken orally or sublingually, or under the tongue. It is important to remember that taking it sublingually can speed up the onset, the coluracetam’s effect will be stronger, and a much smaller dose will be effective.


The recommended dosage lies between 5 and 60 mg per day. Typically, this recommended dose should be divided into two equal daily doses. However, it is also best to start with small doses to judge the effects and reduce the likelihood of side effects.

Higher doses are often required for depression and anxiety. If this is the reason you are interested in this nootropic, you will still want to start with small dosages, but you may have to increase the coluracetam dosage up to 30 mg or more at two doses per day.

What is The Half-life?

The half-life of coluracetam is rapid, somewhere between 1 and 3 hours. This means that after that amount of time, half of the dose will be gone and ineffective.

However, this does not mean you should take a dose every hour because the duration is much longer than that.

For a large dose, the onset can be as short as 15 minutes, but a heavy dose can take up to an hour to take effect. The recommended dosage will provide the desired effects of coluracetam for 3 to 6 hours.

Coluracetam Stacks

Coluracetam can be a superb addition to a stack of nootropics, and there are a few joint dietary supplements that can boost the effectiveness.

Coluracetam and Choline Stack

Coluracetam works well with a choline source to enhance the choline uptake benefits.

Substances and supplements like Alpha-GPC or CDP Choline can enhance the stack’s improved memory and cognition effects.

For this combination, start with 5 to 10 mg Coluracetam, two times daily and 300-600 mg Alpha GPC or 250-750 mg CDP Choline.

Coluracetam, Caffeine and L-Theanine Stack

This stack combination is excellent for boosting energy and mood. Since L-theanine provides an energetic but calm feeling that can be good for anxiety, caffeine provides stimulating energy.

This stack can offer excellent results in the morning to start the day.

This combination works best when you take 5 to 10 mg of Coluracetam twice daily, one dose of L-theanine at 100 mg daily, and caffeine at 100 to 200 mg.

Coluracetam and Aniracetam Stack

This stack is a wonderful combination for better confidence, motivation, and social fluency.

It also helps to increase the influence on acetylcholine and the qualities that it helps with, like memory, attention, and cognition.

Take 5 to 10 mg Coluracetam and 750 mg Aniracetam for this combo, both twice a day.

Does Coluracetam Have Side Effects?

While coluracetam is regarded as safe, there are some potential side effects and warnings that you should keep in mind.

If you have a personal experience with a mild or severe side effect, it is best to decrease the dosage or stop taking it altogether to resolve the issues.

In addition, taking a choline source can help lower the risk or alleviate side effects caused by the high-affinity choline uptake.

Too much can cause lethargy and can lead to glutamate cytotoxicity as well if we produce too much, which can harm neurons.

Some of the most common side effects include nervousness, headaches, dizziness, and nausea. It may also affect sleep if you take the supplements too late in the day, making headaches worse.

Avoid taking this substance with another drug, even if it is prescribed. While an interaction may be rare, avoiding taking it with medication can minimize the risk.

Tolerance can also become an issue. Because of that, it is best to cycle the nootropics as it can significantly reduce the risk of tolerance. We recommend 2 months on, 2 weeks off. This will also help the AMPA receptors function well when you return to the product.

Where To Buy Coluracetam?

Coluracetam offers a lot of beneficial features, but where can you buy coluracetam? It is available in most stores that carry nootropics. The quality, however, can vary significantly from one to the next.

Our experiences and expertise have led us through the good and bad products available at locations where you can buy coluracetam.

We recommend to buy coluracetam from PureRawz as the company always offer potent and contaminate-free products at a reasonable price. Plus, they even guarantee your satisfaction and offer your money back within 30 days.


As a solid nootropic choice, coluracetam boosts memory capacity, brain health, and mood. This makes it an exceptional choice for those who have distracting thoughts, poor memory, anyone looking to attain a cognitive edge and prevent the mental woes that come with older ages.

There are some side effects to keep in mind, and taking too much can cause dizziness, grogginess, and other negative ailments. So it would be best if you always were cautious when starting the product.

Still, though, it can be an impressive addition to nootropics stacks and balancing out the impact of the effects.

Students and white-collar workers most commonly use it, but the popularity of this newer supplement is expanding rapidly into all demographics.

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