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Tara Lamont & Dr Vasee Moorthy

Research & Dissemination
13:00 Monday June 18th

Abstracts

Dr Vasee Moorthy, Coordinator Research, Ethics, Knowledge Uptake, WHO Geneva – What are the next steps in enabling dissemination of clinical trial results?: WHO’s perspective
While the many compelling reasons for requiring reporting of clinical trials results are well known, compliance, policy and legislatory development  remains incomplete. In this talk Dr Moorthy will summarise WHO’s work in bringing research funders together to develop policies that require registration and  results disclosure, and discusses possible next steps with other stakeholders in the clinical trial ecosystem.

Tara Lamont, Deputy Director, NIHR Dissemination Centre – Ways of making evidence used and useful in a world of information overload
Evidence does not speak for itself.  Effort is needed by researchers to make sense of their findings in ways that are meaningful to wider audiences.  That means understanding who the audience is and the context in which they work and live.  We can learn from experts in communication, marketing and persuasion.  There is also some evidence about what works in terms of formats of research-based outputs which are most likely to be taken up by decision-makers.  I will talk about the work of the NIHR Dissemination Centre in packaging up evidence and framing findings for non-academic audiences.  Our experience over the last three years has made us think about principles of good dissemination, which I will describe in terms of who, what, how and when.  I will share our experience and pointers from a wide range of sources and examples of research which has had reach and impact for service audiences.

Bio’s

Tara Lamont has worked for over twenty five years in health services research, audit and patient safety.  Since 2015, she has been deputy director of the NIHR Dissemination Centre, finding new ways to share evidence with decision-makers in health and care.  Before that, she acted as scientific advisor to an NIHR research programme focused on health services delivery and set up a new national patient safety function to deliver evidence on clinical risks to practitioners. She is an editor for the NIHR Journals Library, member of the HSRUK Board and writes widely in a personal capacity on health services research topics, including recent BMJ Group blogs.

Dr Vasee Moorthy (BA MA BMBCh MRCP PhD) leads the Research, Ethics and Knowledge Uptake Unit at WHO’s Department of Information, Evidence and Research in Geneva. The unit coordinates WHO’s work in health research including the Global Observatory on Health R&D, the Global Clinical Trials Registration standards and database (www.who.int/ictrp), WHO’s work in global health ethics (bioethics, research ethics and public health ethics) and in translation of research to policy through quality oversight of development of WHO evidence-based guidelines. Dr Moorthy coordinates WHO clinical trials policy, assisting in development of the 2017 WHO Joint Statement on Public Disclosure of Results from clinical trials, signed by 21 leading funding agencies and NGOs globally. Prior to Jan 2017, he led the Vaccine Development Team at WHO Initiative for Vaccine Research.  The portfolio of activities for the WHO Vaccine Development Team includes HIV, tuberculosis, malaria vaccines, RSV, Group A & B streptococcal disease, ETEC, Shigella and Norovirus, and WHO’s work in preclinical, and Phase 1-2 clinical vaccine evaluation for emerging pathogens including filoviruses and MERS-CoV. He leads development of WHO TPPs in emerging infection. During the 2014-2016 Ebola emergency he led WHO’s work coordinating the acceleration of Ebola vaccine R&D into Phase 1 and Phase 2 vaccine trials in USA, Canada, Europe and Africa. He is one of the 3 co-leads for the R&D Blueprint, which builds on the R&D acceleration work initiated by WHO during the Ebola crisis, currently supporting a national Nigerian lassa fever research plan and response.

He is an infectious disease subspecialist physician with a clinical medicine degree (BMBCh) from the University of Oxford, a BA in Natural Sciences (University of Cambridge 1st class honours) and experience working as a general medical officer for the South African government in the 1990s in a rural district general hospital (Hlabisa hospital in Kwazulu-Natal). He gained a PhD for clinical immunology studies conducted in The Gambia from 1999 to 2002 as part of malaria vaccine clinical trials. He has previously worked as a Senior Program Officer at PATH based in Bethesda, MD, USA with responsibility for malaria vaccine clinical trials in USA, Europe, Africa and India. Dr Moorthy has been an employee of the World Health Organization since 2009, where he initially acted as WHO’s malaria vaccine focal point. In that initial role at WHO he coordinated the global funders group for malaria vaccines, and developed consensus on methods including key efficacy endpoints and clinical case definitions for the large Phase 3 trial of the RTS,S/AS01 malaria vaccine that occurred in 7 African countries. He was the WHO secretariat lead responsible for the evidence appraisal and synthesis leading to WHO policy recommendations on RTS,S/AS01 together with coordinating the initiation of the malaria vaccine pilot programme during 2016 in Kenya, Ghana, Malawi.

Bio – Tara has worked for over twenty years in health services research, audit and patient safety.  She acted as scientific advisor to an NIHR research programme focused on health services delivery and set up a new national patient safety function to deliver evidence on clinical risks to practitioners. She is an editor for the NIHR Journals Library, member of the HSRUK Board and writes widely in a personal capacity on health services research topics, including recent BMJ Group blogs.

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